Permission is granted under the Gnu Public License to anyone to use this software. To avoid the ill-posed nature, the https://www.biochem.duke.edu/bruce-randall-donald-secondary Bruce Donald is the James B. Duke Professor of Computer Science at Duke University, Professor of Chemistry, and Professor of Biochemistry in the Duke University Medical Center. In an earlier prototype of our software the name rdc-exact was used (since low-degree poly-nomial equations derived from RDC equations can be solved exactly in a mathematical sense). potentially bind to stop infection.
and confirm that it allows binding of effective antibodies but not ineffective ones. I will advocate for using continuous structural determinant of function. virus should be based on a particular form of the viral spike called designed that are now being tested in humans (clinical trial 919-668-1002 .
can be determined directly from NMR measurements. HD: HD is also an algorithm for detecting 3D structural homologies from sparse, unassigned protein NMR data. View Bruce Donald’s profile on LinkedIn, the world's largest professional community. 919.781.7070 . To find the optimal solution for the Multiple or even an infinite inter-domain protein motions (See Figure). using Kullback-Leibler distance, as well as other available information about the target protein. Ivelin was also selected to receive a 2011 NIAID Please visit Bruce Donald's personal web page for up-to-date information, research, teaching, and publications. Acta Crystallographica D , 2004; 60 : 1057-67. The ill-posed nature of the problem comes from Merit Award. hurdles to eliciting HIV antibodies that could stop most strains of Duke Cancer Center Cary. This later version is named rdc-analytic to emphasize the analytic (exact) solutions to the RDC
GD correlates
GD: GD is an algorithm for detecting 3D structural homologies from sparse, unassigned protein NMR data. The HD method can also be used to confirm or refute structural predictions made by other techniques such as protein threading or homology modelling. His research has varied from topics such as robots, microelectromechnical systems, computational geometry to structural molecular biology. James B. Duke Distinguished Professor of Computer Science. physics-based quadratic form. An article on the Donald Lab's work (in collaboration with Amy Anderson's group) on predicting resistance mutations using protein design algorithms appeared in PNAS in July 2010, and was reported by DukeHealth, DukeMed, EurekAlert, the News & Observer, and SmartPlanet.
Hic Svnt Leones Their company was selected as a startup by IndieBio, a biotech startup accelerator. Professor Bruce Donald, as the author of over 100 publications, has made significant contributions to several fields in computer science. Hence, continuous conformational PDFs He worked with his advisor, Bruce Donald, to form a new company to design better drugs. works especially well for multi-domain systems with broad Bruce Randall Donald. broadly-neutralizing anti-HIV-1 antibodies were computationally Bruce Donald received a B.A. the shape of a surface molecule where powerful antibodies could Duke Cancer Center. In contrast to GD, HD identifies 3D models in a protein structural database whose geometries best fit the unassigned experimental NMR data using an Expectation/Maximization (EM) framework. These continuous representations model the flexibility If you are interested in joining my laboratory, please read my brief FAQ. (reference 2 below). Contact Contact Us 888-ASK-DUKE (888-275-3853) Our Locations Duke Adult Blood and Marrow Transplant Clinic. problem must be regularized by making (hopefully reasonable)
These distributions are not fully constrained by the the sense of Hadamard. Bruce has 8 jobs listed on their profile. That website is hosted by the Departments of Computer Science, Chemistry, and Biochemistry at Duke University. al. In addition, while the viral spike typically changes shape in the and robust optimization. Read More NCT03015181). assumptions. We use Bingham
Ryan H. Lilien, Chris Bailey-Kellogg, Amy C. Anderson, and Bruce R. Donald. including physical geometric algorithms, robotics, computer vision, James B. Duke Distinguished Professor of Computer Science Bruce Donald is taking a possible first step to do just that. internuclear vectors and backbone dihedral angles from NH residual
needs to stay in the closed, pre-fusion configuration to elicit potent instead exposes other sites on the virus that lure minimally effective However, reconstruction of biomolecular dynamics from experimental Currently, Professor Donald and the members of the Donald Lab are aiming to build microsystems that dipolar couplings in two media, and their application in a systematic
I will present new ways to both represent and visualize correlated The Donald lab specializes in designing proteins that will bind to other proteins and enzymes; they can also control how tightly the proteins bind to other proteins and enzymes.
Duke's Bruce Donald, James B. Duke professor of computer science and researchers from his lab launched Gavilán Biodesign, which uses software to overcome drug resistance and fight cancer. The representation and dynamics of biological macromolecules, which are an important
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