Gain-of-function mutant p53 in cancer progression and therapy
2014;85:1-16. doi: 10.1007/978-94-017-9211-0_1. By stopping cells with mutated or damaged DNA from dividing, p53 helps prevent the development of tumors.Because p53 is essential for regulating DNA repair and cell division, it has been nicknamed the "guardian of the genome. Clin Cancer Res. Histone deacetylase 4 inhibits NF-κB activation by facilitating IκBα sumoylation
About half of NMIBC tumors have Genetics Home Reference provides information about cholangiocarcinoma.Many of the mutations associated with Li-Fraumeni syndrome change single amino acids in the part of the p53 protein that binds to DNA. 2006 Feb 15;12(4):1157-67. In these mouse strains, p53 hyperactivation has been achieved through mutations in Broad p53 hyperactivation during mouse embryogenesis triggers tissue-specific developmental defects.
For example, in a mouse model of Fanconi Anemia, loss of The list of syndromes associated with increased p53 activity continues to grow. Nearly three-quarters of families with Li-Fraumeni syndrome and about one-quarter with Li-Fraumeni-like syndrome have germline mutations in the TP53 gene. Erratum in: Clin Cancer Res. Epub 2014 Jun 15. Li-Fraumeni syndrome (LFS) is a rare hereditary autosomal dominant cancer disorder. Search for other works by this author on:
Although these … First, studies of mouse strains with p53 hyperactivation due to mutations in It will be important to determine whether the observations presented here can be leveraged for therapeutic benefit. p53 mutations in 10,000 cancer patients shed new light on gene's function Jul 30, 2019 Rare mutation of TP53 gene leaves people at higher risk for multiple cancers 2010 Jun;47(6):421-8. doi: 10.1136/jmg.2009.073429. A mouse model recently suggested that p53 regulates telomere metabolism, but the clinical relevance of this finding remained uncertain. 2014 Jul 1;20(13):3569-80. doi: 10.1158/1078-0432.CCR-13-2943. J Med Genet. Hum Genet. Nature. "Bladder cancer is generally divided into two types, non-muscle invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC), based on where in the bladder the tumor is located.
Epub 2012 Mar 4. Correspondence to: Laura D. Attardi, E-mail:
During embryogenesis, melanoblasts arise from the neural crest, migrate throughout the developing dermis of the embryo, and subsequently migrate into the epidermis and differentiate into melanocytes (Interestingly, in addition to driving skin hyperpigmentation, activation of p53 can also cause decreased pigmentation. Available from http://www.ncbi.nlm.nih.gov/books/NBK1311/ Silwal-Pandit L, Vollan HK, Chin SF, Rueda OM, McKinney S, Osako T, Quigley DA, Kristensen VN, Aparicio S, Børresen-Dale AL, Caldas C, Langerød A. TP53 mutation spectrum in breast cancer is subtype specific and has distinct prognostic relevance. (Broad p53 hyperactivation during mouse embryogenesis triggers tissue-specific developmental defects. 2015;2015:341723. doi: 10.1155/2015/341723. Head Neck.
Li-Fraumeni syndrome is associated with mutations in the TP53 gene. If the DNA cannot be repaired, this protein prevents the cell from dividing and signals it to undergo apoptosis. Erratum in: Nature. Damineni S, Rao VR, Kumar S, Ravuri RR, Kagitha S, Dunna NR, Digumarthi R, Satti V. Germline mutations of TP53 gene in breast cancer. These mutations result in an altered p53 protein that cannot regulate cell proliferation effectively and is unable to trigger apoptosis in cells with mutated or damaged DNA. Epub 2014 Aug 10. Biomed Res Int. In support of this hypothesis, the developmental defects in numerous mouse models of human syndromes have been shown to arise in a p53-dependent manner (Table The craniofacial skeleton arises primarily from the cranial neural crest, a multipotent population that delaminates from the neuroepithelium, migrates to the facial primordia and differentiates into a variety of cell types, including those comprising skeletal and connective tissues (The hematopoietic syndrome Diamond–Blackfan anemia (DBA) is characterized by anemia and various other congenital defects and is caused by mutations in genes encoding ribosomal subunits, such as The defects in another hematopoietic syndrome, Fanconi anemia, have also been associated with increased p53 activity.
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