J. Immunol. In this scenario, the spleen becomes the crucial hub allowing the interaction of different systems differently involved in metabolic and cardiovascular diseases. Cell Biol. This blood reserve has a high count of platelets, an essential component for blood coagulation to help stop bleeding. 5, 325331.Dailey, M. O., Coleman, C. N., and Kaplan, H. S. (1980) Radiation-induced splenic atrophy in patients with Hodgkins disease and non-Hodgkins lymphomas. The spleen also stores red blood cells, platelets, and infection-fighting white blood cells. Spleen enlargement or splenomegaly can occur due to viral mononucleosis, liver cirrhosis, lymphoma, leukemia and other diseases.
(1997) T cell priming against vesicular stomatitis virus analyzed in situ: red pulp macrophages, but neither marginal metallophilic nor marginal zone macrophages, are required for priming CD4+ and CD8+ T cells. Occasionally, the spleen becomes so large – massive splenomegaly – it pushes on nearby organs and blood vessels. 190, 1165-1174.Ochsenbein, A. F., Pinschewer, D. D., Odermatt, B., Ciurea, A., Hengartner, H., and Zinkernagel, R. M. (2000) Correlation of T cell independence of antibody responses with antigen dose reaching secondary lymphoid organs: implications for splenectomized patients and vaccine design. Am.
Yet without your spleen, you will be more likely to get certain infections. As the largest organ in the army of defense, it’s got an important role – acting as an external barrier keeping germs from getting inside your body. Med. Curr.
(See also Overview of Immunodeficiency Disorders.) A., and Flavell, R. A. It is an emergency situation that requires surgical removal of the spleen. J. Immunol. 131, 1240 - 1245.Fu, Y. X., Huang, G., Wang, Y., and Chaplin, D. D. (1998) B lymphocytes induce the formation of follicular dendritic cell clusters in a lymphotoxin a-dependent fashion. It affects the number of red blood cells that carry oxygen throughout your body, and the number of platelets, which are cells that help your blood to clot. Timens, W., Boes, A., and Poppema, S. (1989) Human marginal zone B cells are not an activated B cell subset: strong expression of CD21 as a putative mediator for rapid B cell activation. Medical Embryology. Eur. (1997) Pooled normal human polyspecific IgM contains neutralizing anti-idiotypes to IgG autoantibodies of autoimmune patients and protects from experimental autoimmune disease. (1998) A critical role of natural immunoglobulin M in immediate defense against systemic bacterial infection. 2. Other organs serve some functions similar to those of the spleen. (1980) Immunohistologic analysis of the organization of normal lymphoid tissue and non-Hodgkins lymphomas. J. Pathol. Timens, W. and Poppema, S. (1985) Lymphocyte compartments in human spleen. All rights reserved. B. and Parish, C. R. (1995) Are murine marginal-zone macrophages the splenic white pulp analog of high endothelial venules ? Cytol. Exp. Opin. It’s an important organ, but not essential. Transplant. Zotero 223, 152-157.Dempsey, P. W., Allison, M. E., Akkaraju, S., Goodnow, C. C., and Fearon, D. T. (1996) C3d of complement as a molecular adjuvant: bridging innate and acquired immunity. Sci. Ann. Rev. The surgery to remove your spleen is called a splenectomy.Your lymph nodes and liver can take over many of the spleen’s important functions. Proc. Sanders, L. A., van de Winkel, J. G., Rijkers, G. T., Voorhorst-Ogink, M. M., de Haas, M., Capel, P. J., and Zegers, B. J.
J. Med. J. Immunol. Zotero 110, 183 - 190.Crowley, M., Inaba, K., and Steinman, R. M. (1990) Dendritic cells are the principal cells in mouse spleen bearing immunogenic fragments of foreign proteins. Exp. Avoid contact sports and other high-impact activities until cleared by your doctor.Yes, you can live without your spleen. J. Immunol. McKenzie, S. E. and Schreiber, A. D. (1998) Fc?
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