The research paper of Dr. Satishchandra Philkhana titled "Identification of new anti-inflamatory agents based on nitrosporeusine natural products of marine origin" got accepted in The research paper of Dr. Satishchandra Philkhana titled "Total synthesis of natural Fregenedadiol and its diacetate, rearranged labdanes with aromatized B ring"Mycalol Analogues with Improved Potency against Anaplastic Thyroid Carcinoma Cell Lines" Dr. Srinivasa Reddy has been nominated as a member of Indian Pharmacopoeia Commision (IPC), Govt. x�b```�\V�� cc`a����� ���b�d�`����e�%��ʡ��В,nwN�I���Q�#��i��jQ1���7"��-���, <<6EC11168CA890044A59283ABF0EE8C77>]>> Congratulations Sir ! We have made an attempt towards “Ideal Synthesis” or a step towards “Dial-a-Molecule” by reducing the number of steps, following atom economy, and a green synthetic route.An efficient and convenient method was developed for the synthesis of novel 1,4-oxazepine- and 1,5-oxazocine-based sugar hybrids from readily available deoxysugar azides by means of tributylphosphine-mediated tandem reactions. %%EOF All rights reserved.Electronics & Communication Engineering (MEMS Design Center) Comparison of the biological activities of both enantiomers and the racemate in field trials showed that the (S)-(+)-enantiomer was highly a...Preliminary results from a program aimed at the creation of a focused library of analogues around the natural product peribysin E, a potent biologically active and structurally fascinating molecule, are reported. See the complete profile on LinkedIn and discover D. Srinivasa’s connections and jobs at similar companies. The Shanti Swarup Bhatnagar Prize for the year 2015 in chemical sciences has been awarded to Dr. D. Srinivasa Reddy of CSIR-National Chemical Laboratory (CSIR-NCL), Pune for his outstanding contributions to the area of total synthesis of natural products and medicinal chemistry. A concise synthetic route, use of the under explored Middle aged High end business Entrepreneur gets into company with 30 years of varied Business Experiences in Real Estate, Dairy Farm, and also Quarry industry, handles the procurement of land. Of.
Reddy’s group at NCL in 2010 as a post doctoral Research Associate and carried out total syntheses of several natural products which include, CJ-15801, Diaportheone-B, Microsporin-B and … The main pathogen for urinary tract infections is Escherichia coli and Streptoc...Towards the total chemical synthesis of the exceptionally potent antibiotic teixobactin, we synthesized the macrocyclic core of a natural product by using a solution-phase approach. D. Srinivasa Reddy has been appointed as an editor of Bioorgnic & Medicinl Chemistry Letters, Elsevier Publications. The central pyrazole core was also replaced with its conformationally constrained motif and imidazole moieties. 0000004008 00000 n 32. # Jammu # NCL # Sakal # SakalTimes # SakalNews # Viral # News # ViralNews. The first is raltegravir potassium, essentially a member of a new class of compounds that is found to be extremely effective in managing the life‐threatening disease AIDS. endstream endobj 127 0 obj <>/Metadata 3 0 R/PageLayout/OneColumn/Pages 124 0 R/StructTreeRoot 7 0 R/Type/Catalog>> endobj 128 0 obj <>/ExtGState<>/Font<>/XObject<>>>/Rotate 0/StructParents 0/Type/Page>> endobj 129 0 obj <>stream The present effort provides access to sufficient amounts of scarce hunanamycin A for further biological evaluation and confirmation of the assigned absolute configuratio...A simple and efficient synthesis of functionalized cis-hydrindanes and cis-decalins was achieved using sequential Diels-Alder/aldol approach in a highly diastereoselective manner.
%PDF-1.5 %���� In addition, this natural product has a broad range of bioactivities including, ant...Here, we disclose novel mosquito-repellent synthetic hydrindanes based on noreremophilanes and nardoaristolone B which show increased activity against adult females of Aedes aegypti. To address their likely me...The total synthesis of cyclic depsipeptide Met10-teixobactin in solution-phase is described. DOI: 10.1021/acs.joc.9b03129. Many molecules have been reported to possess antiglycation activity, one such example is acetylsalicylic acid (Aspirin). P133 is reported using two complementary routes, a one step and a three-step sequence. ii. and could find applications a...An efficient and convenient method was developed for the synthesis of novel 1,4-oxazepine- and 1,5-oxazocine-based sugar hybrids from readily available deoxysugar azides by means of tributylphosphine-mediated tandem reactions. The total synthesis of (±)-peribysin E was accomplished using a short route. This natural product is known to suppress neuronal spontaneous calcium ion oscillations through its voltage-gated sodium channel blocking ability which is of significant interest in CNS drug discovery. We synthesized cis-hydrindanes based on a naturally occurring noreremophilane scaffold using a Diels-Alder/aldol sequence and screened them for multiple biological activities using high-con...The total syntheses of (±)-botryosphaeridione, (±)-pleodendione, (±)-hoaensieremodione, 4-epi-periconianone B, and their analogues have been accomplished for the first time. ds.reddy@ncl.res.in . Teixobactin, a macrocyclic depsipeptide natural product, isolated from uncultured bacteria (Eleftheria terrae), displayed potent activity against several Gram-posit...A simple and convenient method for the synthesis of α-ketoamides by the oxidation of aryl acetamides using potassium superoxide (KO2) as an oxidizing agent is disclosed here.
0000003931 00000 n Phenotypic screening in Toxoplasma gondii identified 27 delayed death inhibitors, which were found to interfere with apicoplast segregation during daughter cell formation. Reddy’s & TATA Advinus) • Acquired skills in designing novel small molecules and lead optimization • Experienced in planning and execution of total synthesis of biologically active molecules Achievements • Taking a molecule to the human clinical trials where I was a project leader. The developed route is suitable for introducing multiple substitutions on the tetracyclic scaffold. The scope of the developed method is successfully tested with fifteen substrates. This prompted us to revise the originally proposed structure, in particular, the stereochemistry of the nonpeptide part,...An enantiospecific synthesis of Hatakeyama's intermediate enynol has been accomplished in both enantiomeric forms. The present synthesis utilizes a crotylation, oxidative cleavage of the indole moiety, and macrolactamization as key steps. 0000004236 00000 n
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